1. install flex (parser): sudo apt-get install flex 2. install xampp developer package 3. sudo ./configure --with-apxs=/opt/lampp/bin/apxs if you get "apxs:Error: Command failed with rc=65536..." => download the package: https://svn.apache.org/repos/asf/quetzalcoatl/mod_python/trunk 4. After "sudo make", "sudo make install" in http.conf, add following lines: LoadModule python_module modules/mod_python.so <Directory /some/directory/htdocs/test> AddHandler mod_python .py PythonHandler mptest PythonDebug On </Directory> 5. Write test python script "mptest.py": from mod_python import apache def handler(req): req.content_type = 'text/plain' req.write("Hello World!") return apache.OK